RedDino：红细胞分析的基础模型

摘要

紅血球（RBCs）對人體健康至關重要，其精確的形態學分析對於診斷血液疾病具有重要意義。儘管基礎模型在醫學診斷中展現出潛力，但針對紅血球分析的全面人工智慧解決方案仍顯稀缺。本文介紹了RedDino，這是一種專為紅血球影像分析設計的自監督基礎模型。RedDino採用了針對紅血球特徵的DINOv2自監督學習框架改進版，並基於精心挑選的125萬張來自不同採集方式和來源的紅血球影像數據集進行訓練。廣泛的評估表明，RedDino在紅血球形態分類任務上超越了現有的頂尖模型。通過包括線性探測和最近鄰分類在內的多項測試，我們確認了其強大的特徵表示能力和泛化性能。我們的主要貢獻包括：（1）專為紅血球分析定制的基礎模型，（2）探索DINOv2配置用於紅血球建模的消融研究，以及（3）對泛化性能的詳細評估。RedDino通過捕捉細微的形態特徵，解決了計算血液學中的關鍵挑戰，推動了可靠診斷工具的發展。RedDino的源代碼及預訓練模型可在https://github.com/Snarci/RedDino獲取，預訓練模型亦可從我們的Hugging Face集合https://huggingface.co/collections/Snarcy/reddino-689a13e29241d2e5690202fc下載。

English

Red blood cells (RBCs) are essential to human health, and their precise morphological analysis is important for diagnosing hematological disorders. Despite the promise of foundation models in medical diagnostics, comprehensive AI solutions for RBC analysis remain scarce. We present RedDino, a self-supervised foundation model designed for RBC image analysis. RedDino uses an RBC-specific adaptation of the DINOv2 self-supervised learning framework and is trained on a curated dataset of 1.25 million RBC images from diverse acquisition modalities and sources. Extensive evaluations show that RedDino outperforms existing state-of-the-art models on RBC shape classification. Through assessments including linear probing and nearest neighbor classification, we confirm its strong feature representations and generalization ability. Our main contributions are: (1) a foundation model tailored for RBC analysis, (2) ablation studies exploring DINOv2 configurations for RBC modeling, and (3) a detailed evaluation of generalization performance. RedDino addresses key challenges in computational hematology by capturing nuanced morphological features, advancing the development of reliable diagnostic tools. The source code and pretrained models for RedDino are available at https://github.com/Snarci/RedDino, and the pretrained models can be downloaded from our Hugging Face collection at https://huggingface.co/collections/Snarcy/reddino-689a13e29241d2e5690202fc

RedDino：红细胞分析的基础模型

RedDino: A foundation model for red blood cell analysis

摘要

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