RedDino：红细胞分析的基础模型

摘要

红细胞（RBCs）对人体健康至关重要，其精确的形态学分析对于诊断血液系统疾病具有重要意义。尽管基础模型在医学诊断中展现出巨大潜力，但针对红细胞分析的全面AI解决方案仍然稀缺。我们提出了RedDino，这是一种专为红细胞图像分析设计的自监督基础模型。RedDino采用了DINOv2自监督学习框架的RBC特定适配版本，并在一个包含125万张来自不同采集方式和来源的红细胞图像的精选数据集上进行了训练。广泛的评估表明，RedDino在红细胞形状分类任务上超越了现有的最先进模型。通过包括线性探测和最近邻分类在内的多种评估方法，我们验证了其强大的特征表示能力和泛化性能。我们的主要贡献包括：（1）一个专为红细胞分析定制的基础模型，（2）探索DINOv2配置用于红细胞建模的消融研究，以及（3）对泛化性能的详细评估。RedDino通过捕捉细微的形态特征，解决了计算血液学中的关键挑战，推动了可靠诊断工具的发展。RedDino的源代码和预训练模型可在https://github.com/Snarci/RedDino获取，预训练模型也可从我们的Hugging Face集合中下载，地址为https://huggingface.co/collections/Snarcy/reddino-689a13e29241d2e5690202fc。

English

Red blood cells (RBCs) are essential to human health, and their precise morphological analysis is important for diagnosing hematological disorders. Despite the promise of foundation models in medical diagnostics, comprehensive AI solutions for RBC analysis remain scarce. We present RedDino, a self-supervised foundation model designed for RBC image analysis. RedDino uses an RBC-specific adaptation of the DINOv2 self-supervised learning framework and is trained on a curated dataset of 1.25 million RBC images from diverse acquisition modalities and sources. Extensive evaluations show that RedDino outperforms existing state-of-the-art models on RBC shape classification. Through assessments including linear probing and nearest neighbor classification, we confirm its strong feature representations and generalization ability. Our main contributions are: (1) a foundation model tailored for RBC analysis, (2) ablation studies exploring DINOv2 configurations for RBC modeling, and (3) a detailed evaluation of generalization performance. RedDino addresses key challenges in computational hematology by capturing nuanced morphological features, advancing the development of reliable diagnostic tools. The source code and pretrained models for RedDino are available at https://github.com/Snarci/RedDino, and the pretrained models can be downloaded from our Hugging Face collection at https://huggingface.co/collections/Snarcy/reddino-689a13e29241d2e5690202fc

RedDino：红细胞分析的基础模型

RedDino: A foundation model for red blood cell analysis

摘要

Support